This project is funded by the European Union
Increasing Prevention and Treatment of TB
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Dr Shea Hamilton PhD
Postdoctoral Scientist
Previous Roles
Postdoctoral Researcher (2007-Present). Department of Paediatrics, Imperial College London. Identification of Serum Biomarkers of Paediatric TB using SELDI.
Postdoctoral Researcher (2005- 2007). Institute of Reproductive and Developmental Biology and Department of Paediatrics, Imperial College London. Investigating the transcriptomic and proteomic response of foetal membrane to infection by Fusobacterium nucleatum using microarrays and SELDI mass spectroscopy.
Ph.D. (2001-2005). Department of Molecular Microbiology, University of Exeter and Institute of Food Research, Norwich. Transcriptomic and proteomic approaches to identify genes required for growth and persistence of the foodborne pathogen Salmonella enterica serovar Typhimurium on surfaces.
Research Assistant (2000-2001). University of Exeter. Two 6 month projects: Isolation and sequencing of the bioluminescent glycoprotein Pholasin® and Real-time in situ monitoring of surface colonisation of oral pathogens.
B.Sc. Molecular Biology/ A.Sc. Applied Chemistry (1994-1999). West Virginia State University and University of Exeter.
Role undertaking on the EU Project
Determine the sera protein profiles from all cohorts using Surface Enhanced Laser Desorption Ionised Mass Spectrometry (SELDI)
Use Biomarker pattern software to compare the protein peak intensities between each cohort and select biomarkers specific for the TB cohort
Characterise putative biomarkers for TB disease
Confirm candidate biomarkers by antibody-based methods such as ELISA or ProteinChip preactivates surface arrays
Validate the biomarker suitability on an additional cohort
Last updated: April 1st 2008