Skip to content | Skip to page navigation | Skip to site navigation
home
undergraduate
postgraduate
research
the school and staff
alumni

neuroscience

Dr Dennis Chan

Name: Dr Dennis Chan BSc PhD MB BChir MD FRCP

Academic position: Senior Lecturer in Neurology and Honorary Consultant Neurologist

Research focus
The diagnosis of early dementia. The functions of the human hippocampus and application to the clinical domain.

Current research

  • Identification of biomarkers for preclinical Alzheimer’s disease
  • The role of functional MRI in the diagnosis of early dementia
  • The role of the hippocampus in retrograde memory
  • Cognitive function in CNS inflammatory disorders

Contact details

Trafford Centre for Medical Research
University of Sussex
Falmer, Brighton BN1 9RY

E-mail:

Research Adminstrator

Hazelle Woodhurst

h.woodhurst@bsms.ac.uk

Tel: 01273 873818 01273 265932 (Wednesdays)

NHS Secretary

christine.leach@bsuh.nhs.uk

Tel 01444 441881 x5426
Fax 01444 448641


Qualifications

  • 1988 BSc (Class I), University College London
  • 1992 PhD, University College London
  • 1993 MB BChir, University of Cambridge
  • 1997 MRCP, London
  • 2008 MD, University of Cambridge

Previous Positions

  • 1988-1991 MRC PhD studentship, University College London
  • 1993 Visiting research fellow, The Salk Institute, La Jolla, California
  • 1998-2002 Clinical research fellowship, Dementia Research Group, Institute of Neurology, London

Selected publications

Original articles

Chan D, Anderson VM, Pijnenburg Y, Whitwell JL, Barnes J, Scahill RI, Stevens JM, Barkhof F, Scheltens P, Rossor MN, Fox N (2009) The clinical profile of right temporal lobe atrophy. Brain 132, 1287-1298

Bird CM, Chan D, Hartley T, Pijnenburg Y, Rossor MN, Burgess N (2009) Topographical short-term memory differentiates Alzheimer’s disease from frontotemporal lobar degeneration. Hippocampus (in press)

Lehmann M, Douiri A, Kim L, Modat M, Chan D, Ourselin S, Barnes J, Fox N (2009) Atrophy patterns in Alzheimer’s disease and semantic dementia: a comparison of FreeSurfer and manual volumetric measurements. Neuroimage (in press)

Chan D, Henley S, Rossor MN, Warrington EK (2007) Temporally ungraded retrograde amnesia in encephalitis associated with anotibodies to voltage-gated potassium channels. Arch Neurol 64, 404-410

Hartley T, Bird CM, Chan D, Cipolotti L, Husain M, Vargha-Khadem F, Burgess N (2007) Hippocampal damage selectively impairs topographical processing of spatial scenes over very short delays. Hippocampus 17, 34-48

Schott JM, Fox NC, Frost C, Scahill RI, Janssen JC, Chan D, Jenkins R, Rossor MN (2003) Cerebral atrophy in early familial Alzheimer’s disease: assessing the onset of structural change. Ann Neurol 53, 181-188

Chan D, Walters RJ, Sampson EL, Schott JM, Smith SJ, Rossor MN (2004) EEG abnormalities in frontotemporal lobar degeneration. Neurology 62, 1628-1630

Högh P, Smith SJ, Scahill RI, Chan D, Harvey RJ, Fox NC, Rossor MN (2002) Epilepsy presenting as AD: Neuroimaging, electroclinical features and response to treatment. Neurology 58, 298-301

Chan D, Janssen JC, Whitwell J, Watt HC, Jenkins R, Frost C, Rossor MN, Fox NC (2003) Rates of cerebral atrophy in early onset Alzheimer’s disease increase with disease severity: a longitudinal MRI study. Lancet 362, 1121-1122

Good C, Scahill RI, Fox NC, Ashburner J, Friston KJ, Chan D, Crum WR, Rossor MN, Frackowiak RSJ (2002) Automatic differentiation of anatomical patterns in the human brain: validation with studies of degenerative dementias. Neuroimage 17, 29-46

Chan D, Fox NC, Jenkins R, Scahill RI, Crum WR, Rossor MN (2001) Rates of regional and global cerebral atrophy in AD and frontotemporal dementia. Neurology 57, 1756-1763

Chan D, Crutch SJ, Warrington EK (2001) A disorder of colour perception associated with abnormal colour after-images: a defect of primary visual cortex. J Neurol Neurosurg Psychiatr 71, 515-517

Cipolotti L, Shallice T, Chan D, Fox NC, Scahill RI, Harrison G, Stevens JM, Rudge P (2001) Long term retrograde amnesia: the crucial role of the hippocampus. Neuropsychologia 39, 151-172

Chan D, Rossor MN (2002)  "-But who is that on the other side of you?" Extracampine hallucinations revisited. Lancet 360, 2064-2067

Chan D, Revesz T, Rudge P (2002) Hippocampal, but not parahippocampal, damage in a case of dense retrograde amnesia: a pathological study. Neurosci Lett  329, 61-64

Chan D, Fox NC, Scahill RI,  Crum WR, Whitwell J, Leschziner G, Rossor A, Stevens JM, L. Cipolotti L, Rossor MN (2001) Patterns of temporal lobe atrophy in semantic dementia and Alzheimer’s disease. Ann Neurol  49, 433-442

Books and chapters

Walker, MC, Chan D, Thom M (2007) The hippocampus in human disease. In: The Hippocampus Book. Editors: Andersen P, Morris RGM, Amaral DG, Bliss TPM, O’Keefe J. Oxford University Press.