neuroscience
Name: Professor Hugo Critchley MBChB DPhil MRCPsych
Academic position: Chair in Psychiatry
Contact details:
Clinical Imaging Sciences Centre
(CISC)
Brighton and Sussex Medical School
University of Sussex
Falmer, Brighton BN1 9RR, UK
Tel: +44 (0) 1273 678336
E-mail:
Research focus:
My long term interest is the control of emotional and motivational behaviour. I now focus on examining psychophysiological mechanisms underlying symptom expression in physical and psychological disorders; i.e. how brain and body interact to influence subjective experience, behaviour and physical health. Techniques typically combine functional brain imaging with autonomic monitoring and clinical studies of relevant patients. This work extends into behavioural medicine and is supported by the Wellcome trust.
Publications 2007-present
in press
- Influence of sympathetic autonomic arousal on tics: Implications for a therapeutic behavioural intervention for Tourette Syndrome J Psychosomatic Research. Nagai Y, Cavanna A, Critchley HD 2009 in press
- An fMRI study of the effect of sacral neuromodulation on brain responses in women with Fowler’s Syndrome Kavia R, DasGupta R, Critchley H, Fowler CJ, Griffiths D BJU International 2009 in press
- A common role of insula in feelings, empathy and uncertainty Singer T, Critchley HD, Preuschoff K Trends in Cognitive Neuroscience (TICS) 2009 in press
2009
- Physiological recordings: Basic concepts and implementation during functional magnetic resonance imaging. Gray MA, Minati L, Gianaros PJ, Harrison NA, Napadow V, Critchley HD. Neuroimage 2009 online
- Vulnerability to simple faints is predicted by regional differences in brain anatomy. Beacher F, Gray MA, Mathias CJ, Critchley HD Neuroimage 2009 online
- Inflammation causes mood change through alterations in subgenual cingulate activity and mesolimbic connectivity. Harrison NA, Brydon L, Walker C, Gray MS, Steptoe A, Critchley HD. Biological Psychiatry online
- Neural origins of human sickness in interoceptive responses to inflammation Harrison NA, Brydon L, Walker C, Gray MS, Dolan RJ, Steptoe A, Critchley HD. Biological Psychiatry online
- The interaction of activation-repolarisation coupling and restitution properties in humans. Hanson B, Sutton P, Elameri N, Gray M, Critchley H, Gill J, Taggart P. Circulation: Arrhythmia and Electrophysiology 2009 doi:10.1161/CIRCEP.108.785352
- Gianaros PJ, Sheu LK, Remo AM, Christie IC, Critchley HD, Wang JJ Resting perfusion of corticolimbic brain areas predicts individual differences in stressor-evoked blood pressure reactivity. Hypertension 2009 May online
- Gray MA, Rylander K, Harrison NA, Wallin BG, Critchley HD. Following one’s heart: Cardiac rhythms gate central initiation of sympathetic reflexes. Journal of Neuroscience 2009 29:1817-25.
- The Rebirth of Neuroscience in Psychosomatic Medicine, Part II: Clinical Applications and Implications for Research Richard D. Lane RD, Waldstein SR, Critchley HD, Derbyshire S, Drossman DA, Wager T, Schneiderman N, Chesney MA, Jennings JR, Lovallo WR, Rose RM, Thayer JF, Cameron OG. Psychosomatic Medicine 2009 71135-51.
- Changes in cortical potential associated with modulation of sympathetic activity in patients with epilepsy Nagai Y, Critchley HD, Asselman P, Rothwell JC, Duncan JS, Trimble MR. Psychosomatic Medicine 2009 71:84-92.
2008
- Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans. Brydon L, Harrison NA, Walker C, Steptoe A, Critchley HD. Biol Psychiatry. 2008 63:1022-9.
- Controlling emotional expression: behavioral and neural correlates of nonimitative emotional responses. Lee TW, Dolan RJ, Critchley HD. Cereb Cortex. 2008 18:104-13.
- Autonomic contributions to empathy: Evidence from patients with primary autonomic failure Chauhan B, Mathias CJ, Critchley HD. Autonomic Neuroscience: Basic and Clinical 2008 140:96-100
- Blocking central opiate function modulates hedonic impact and anterior cingulate response to rewards and losses. Petrovic P, Pleger B, Seymour B, Kloppel S, De Martino B, Critchley H, Dolan RJ Journal of Neuroscience 2008 28:10509-16.
- Dynamic pupillary exchange engages brain regions encoding social salience. Harrison NA, Gray MA, Critchley HD Social Neuroscience 2008 1:1-11.
- Catatonic signs in Gilles de la Tourette syndrome Cavanna A Robertson MM Critchley HD Cognitive and Behavioural Neurology 2008 21:34-37
- Phenomenology of obsessive compulsive disorder In patients with temporal lobe epilepsy or Tourette Syndrome Mula N, Cavanna AE, Critchley H Robertson MM, Monaco F. Journal of Neuropsychiatry and Clinical Neurosciences 2008 20:223-6
- Anti-basal ganglia antibodies and Tourette’s syndrome: a morphovolumetric study of adults. Martino D, Draganski B, Cavanna, A. Church A, Robertson MM, Frackowiak RSJ, Giovannoni G, Critchley HD. J Neurol Neurosurg Psychiatry. 2008. 79:820-2
- Neuropsychiatric-developmental model for the expression of tics, pervasive developmental disorder, and schizophreniform symptomatology associated with PANDAS. Cavanna AE, Martino D, Orth M, Giovannoni G, Stern JS, Robertson MM, Critchley HD. World J Biol Psychiatry. 2008 3:1-2
- The Gilles de la Tourette syndrome - Quality of Life scale (GTS-QOL): development and validation Cavanna AE, Schrag A, Morley D, Orth M, Robertson MM, Joyce E, Hugo Critchley HD, Selai C Neurology 2008 781:1410-6
- Determinants of health-related quality of life in Gilles del la Tourette Syndrome. Schrag A, Selai A, Robertson M, Orth M, Monaco F, Critchley H, Joyce E,Servo S, Cavanna A Confinia Neuropsychiatrica 2008 2:93-97
2007
- Modulation of emotional appraisal by false physiological feedback during fMRI. Gray MA, Harrison NA, Wiens S, Critchley HD PLoS ONE 2007 2: e546.
- A cortical potential reflecting cardiac function Gray MA, Taggart P, Sutton PM, Holdright DR, Bradbury D, Brull D, Critchley HD. Proceedings of the National Academy of Sciences 2007 104:6818-23
- Incidental processing of pupil size modulates perception of sadness and predicts empathy. Harrison NA, Wilson CE, Critchley HD. Emotion 2007 7:724-9.
- Vagus nerve stimulation for treatment-resistant depression: behavioural and neural effects on encoding negative material. HD Critchley, PA Lewis, M Orth, O Josephs, R Deichmann, MR Trimble, RJ Dolan Psychosomatic Medicine 2007 69:17-22
- Neural correlates of valence and arousal in processing affective words. Lewis P Critchley HD, Rotshtein P Dolan RJ Cerebral Cortex 2007 17:742-8
- Affective neuroscience and psychiatry Harrison NA Critchley HD. British Journal of Psychiatry 2007 191:192-194
- Interoceptive basis to craving. Gray MA, Critchley HD Neuron 2007 54, 183-186
- Perigenual anterior cingulate morphology covaries with perceived social standing. Gianaros PJ, Horenstein JA, Cohen S, Karen A. Matthews KA, Brown SM, Critchley HD. Hariri AR, Manuck SB. Social Cognitive and Affective Neuroscience (SCAN) 2007 2:161-173
- Brain, bicamerality and consciousness Cavanna AE, Trimble MR Critchley HD Servo S. Strigano G, Monaco F. Confinia Neuropsychiatrica 2007, 2 :65-69.
- Deliberate self-harm by insertion of foreign bodies into the forearm, Wraight WJ, Belcher H, Critchley HD J Plast Reconstr Aesthet Surg 2007, doi:10.1016/j.bjps.2007.04.004
- Schizotypal personality traits in Gilles de la Tourette syndrome. Cavanna A Robertson MM, Critchley HD Acta Neurologica Scandinavica 2007 116:385-391