neuroscience
Name: Dr Ricardo Jose Moylan Governo PhD
Academic position: Lecturer in Anatomy, Brighton and Sussex Medical School
Research: Pain, MR Imaging
Contact details:
Brighton and Sussex Medical School
University of Sussex
Falmer
Brighton BN1 9PX
UK
Tel: (+44) 01273 877693
Fax: (+44) 01273 877576
E-mail:
Education:
1999 – 2003 Ph.D. Neuroscience; School of Biomedical Sciences, University of Leeds
1996 – 1999 B.Sc. (Hon.) Human Anatomy; University of Glasgow
1991 – 1994 B.Eng. (Hon.) Aeronautical Engineering; University of Bristol
Positions:
2008 – Present Lecturer in Anatomy; Brighton and Sussex Medical School
2006 – 2008 Postdoctoral Research Fellow; FMRIB Centre, University of Oxford
2003 – 2006 Postdoctoral Research Fellow; School of Biomedical Sciences; University of Nottingham
Short autobiography:
Since graduating in Human Anatomy my research experience has centered on understanding the mechanisms behind the transmission and modulation of nociceptive (pain) information. My post-doctoral posts comprised using MRI scanners as a popular non-invasive tool to identify which brain regions become active following the application of pain, and to what extent painkiller drugs effectively reduce/obliterate that pain.
I am currently employed as a junior lecturer in Anatomy. As a member of the BSMS anatomy team, I am responsible for teaching the anatomy of the abdomen and pelvis to phase I (first and second year) medical students. Our teaching commitment is not only that of lecture-based learning but also to carry out the associated dissection classes, living anatomy tutorials and one-to-one oral exams (vivas). We are also involved in running some student selected components, academic tutorials, and to contribute to the admissions process. Regarding the research aspect of the post, my interest is to resume my MRI work, to look at brain activity in patients suffering from chronic (long lasting) pain.
Research interest:
FMRI analysis, of in vivo whole brain:
BOLD functional activity in specific brain regions in response to vulvodynia, in particular the effect from touching the affected area. Also to investigate the effectiveness of the analgesic quality attributed to antidepressants normally prescribed to alleviate this condition.
Publications:
Journal Papers
Pattinson KT, Governo RJM, MacIntosh BJ, Russell EC, Corfield DR, Tracey I, Wise RG. Opioids depress cortical centers responsible for the volitional control of respiration. Journal of Neuroscience (2009) 29(25), pp 8177-8186
Mitsis GD, Governo RJM, Rogers R, Russell EC, Pattinson KTS. The effect of remifentanil upon respiratory variability, evaluated with dynamic modelling. Journal of Applied Physiology (2009) 106(4), pp 1038-1049
Jones KL, Finn DP, Governo RJM, Prior MJ, Morris PG, Kendall DA, Marsden CA, Chapman V. Identification of discrete sites of action of chronic treatment with desipramine in a model of neuropathic pain. Neuropharmacology (2009) 56(2), pp 405-413.
Governo RJM, Morris PG, Marsden CA, Chapman V. Gabapentin evoked changes in functional activity in nociceptive regions in the brain of the anaesthetised rat – an fMRI study. British Journal of Pharmacology (2008) 153(7), pp 1558-1567
Governo RJM, Prior MJ, Morris PG, Marsden CA, Chapman V. Validation of an automated punctate mechanical stimuli delivery system designed for fMRI studies in rodents. Journal of Neuroscience Methods (2007) 163(1), pp 31-37
Moylan Governo RJ, Morris PG, Prior MJ, Marsden CA, Chapman V. Capsaicin-evoked brain activation and central sensitization in anaesthetised rats: a functional magnetic resonance imaging study. Pain (2006) 126(1-3), pp. 35-45
Governo RJM, Deuchars J, Baldwin SA, King AE. Localisation of the NBMPR-sensitive equilibrative nucleoside transporter, ENT1, in the rat dorsal root ganglion and lumbar spinal cord. Brain Research (2005) 1059(2), pp. 129-138
Ackley MA, Governo RJM, Cass CE, Young JD, Baldwin SA, King AE. Control of Glutamatergic neurotransmission in the spinal dorsal horn by the nucleoside transporter ENT1. Journal of Physiology (2003) 548.2, pp.507-517
Meeting Abstracts
Governo RJM, Rogers R, Russell L, Warnaby CE, Tracey I. (2008) Measuring the duration of analgesic drugs using FMRI. IASP, Glasgow
Warnaby CE, Governo RJM, Wilson IR, Matthews PM, Tracey I. (2008) Reproducibility and sensitivity of pain-related FMRI-BOLD activation responses due to noxious Nd:YAP laser stimulation: a possible tool for analgesic drug discovery. ISMRM
Pattinson KTS, Governo RJM, Russell EC, Rogers R, Tracey I, Wise RG, Mitsis G. (2008) Modelling the effect of remifentanil upon respiratory variability Anaesthesia; 63: 908
Pattinson KT, Governo RJM, Russell EC, MacIntosh BJ, Ahmad I, Mayhew SD, Corfield DR, Tracey I, Wise RG. (2008) The effect of remifentanil upon the conscious control of breathing. ISMRM
Governo RJM, Shah Y, Prior M, Marsden C, Morris P, Chapman V. (2004) Functional magnetic resonance imaging studies of noxious-evoked brain activation in anaesthetised rats. SFN (San Diego meeting) P747.12
Governo RJM, Deuchars J, Ackley MA, Baldwin SA, Cass CE, Young JD, King AE. (2002) Light microscopic and ultrastructural localisation of equilibrative nucleoside transporter immunoreactive profiles in the rat spinal dorsal horn. FENS (Paris meeting) P309
Governo RJM, Ackley MA, Baldwin SA, Berry ZA, Abidi F, Cass CE, Young JD, King AE. (2001) Immunohistochemical localisation of the equilibrative nucleoside transporter rENT1 in the rat spinal dorsal horn. British Neuroscience Association (16th National meeting) 54.05
King AE, Ackley MA, Governo RJM, Berry ZA, Abidi F, Cass CE, Young JD, Baldwin SA. (2001) Localisation and function of the nucleoside transporter ENT1 in the rat spinal dorsal horn in vitro. American Society for Neuroscience (Annual meeting) 719.12
Book Chapters
Governo RJM, Prior MJ, Morris PG, Marsden CA, Chapman V. (2008) Validation of an automated punctate mechanical stimuli delivery system designed for fMRI studies in rodents. In Current awareness in NMR in biomedicine 21: pp 71-78