Skip to main contentSkip to footer
finger pointing scan
Brighton & Sussex Medical School

Our staff

BSMS > About BSMS > Contact us > Staff > Dr Charlotte Rae

Dr Charlotte Rae

Charlotte Rae

Dr Charlotte Rae

Research Fellow
E: C.Rae@bsms.ac.uk
T: +44 (0)1273 873787
Location: Trafford Centre for Medical Research, University of Sussex, Brighton, BN1 9RY

DA: Christina Lee

E: c.lee2@bsms.ac.uk
T: +44 (0)1273 873833

Areas of expertise: Cognitive neuroscience; neuropsychiatry; structural and functional neuroimaging
Research areas: Control of voluntary action in Tourette Syndrome, and influence of autonomic state, emotional reactivity, and neurochemistry; depersonalisation and neural network changes in first-episode psychosis; physiological and interoceptive influences on impulsivity.

BACKGROUND IMAGE FOR PANEL

Biography

Dr Rae completed her PhD in cognitive neuroscience at the MRC Cognition and Brain Sciences Unit in Cambridge in 2013. Her PhD research outlined the structural and functional brain networks that support control of voluntary action. This included training in analysis of structural and effective connectivity techniques using both diffusion imaging and fMRI. She moved to the University of Sussex in 2014 as a postdoctoral Research Fellow at the Sackler Centre for Consciousness Science and the Department of Neuroscience in Brighton and Sussex Medical School.

Research

Dr Rae’s broad interest is in how the human prefrontal cortex supports complex human behaviour, and how this can be altered with everyday challenges and in neurological and psychiatric conditions. Her work within the Sackler Centre for Consciousness Science focuses on questions of how prefrontal networks that support key aspects of consciousness become dysfunctional in brain disorders. In particular, this includes studies on action control in Tourette Syndrome, depersonalisation in first-episode psychosis, and the impact of physiological state on impulsivity. To tackle these questions Dr Rae combines structural and functional MRI brain scanning with measures of autonomic function, physiological state, and psychology tasks measuring participants’ decisions and reactions.

With Sackler Centre colleagues, we have developed novel psychophysiology tasks and analysis methods to translate basic science research into translational consciousness science discoveries. Via Sussex Partnership Trust and industry collaborations, we are also investigating novel therapeutic routes for control of action in dysfunctional prefrontal conditions.

BACKGROUND IMAGE FOR PANEL

Teaching

Dr Rae contributes to teaching both within BSMS and at the University of Sussex, lecturing on BSMS Neuroscience module 202, and the Neuroscience of Consciousness module as part of the School of Psychology’s MSc Cognitive Neuroscience.

Dr Rae supervises research projects for Masters students in the School of Psychology, and intern students within the Sackler Centre for Consciousness Science. 

Selected publications

Polyanska L, Critchley HD, Rae CL, (2017) Centrality of prefrontal and motor preparation cortices to Tourette Syndrome revealed by meta-analysis of task-based neuroimaging studies. 

Rae CL, Davies G, Garfinkel SN, Gabel MC, Dowell NG, Cercignani M, Seth AK, Greenwood KE, Medford N, Critchley HD, (2017) Deficits in Neurite Density Underlie White Matter Structure Abnormalities in First-Episode Psychosis.

Rae CL, Nombela C, Rodríguez PV, Ye Z, Hughes LE, Jones PS, Ham T, Rittman T, Coyle-Gilchrist I, Regenthal R, Sahakian BJ, Barker RA, Robbins TW, Rowe JB (2016) Atomoxetine restores the response inhibition network in Parkinson's disease.

Ye Z, Rae CL, Nombela C, Ham T, Rittman T, Jones PS, Vazquez Rodriguez P, Coyle-Gilchrist I, Regenthal R, Altena E, Housden CR, Maxwell H, Sahakian BJ, Barker RA, Robbins TW, Rowe JB. (2016) Predicting beneficial effects of atomoxetine and citalopram on response inhibition in Parkinson's disease with clinical and neuroimaging measures. Human Brain Mapping, 37(3):1026-1037.

Rae CL, Hughes LE, Anderson MC, Rowe JB (2015) The prefrontal cortex achieves inhibitory control by facilitating subcortical motor pathway connectivity

Rae CL, Hughes LE, Weaver C, Anderson MC, Rowe JB (2014) Selection and stopping in voluntary action: a meta-analysis and combined fMRI study

Rae CL, Correia MM, Altena E, Hughes LE, Barker RA, Rowe JB (2012) White matter pathology in Parkinson's disease: the effect of imaging protocol differences and relevance to executive function

See more >