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Dr Simon Waddell

SimonWaddell

Dr Simon Waddell (BSc, PhD, FHEA)

Senior Lecturer in Microbial Pathogenesis
E: S.Waddell@bsms.ac.uk
T: +44 (0)1273 877572
Location: Room 1.08, BSMS Medical Research Building, University of Sussex, Falmer, Brighton, BN1 9PX

Other Roles: Module leader for BSMS 404 ‘4th Year Independent Research Project’; Chairman of the CL3 users committee

Areas of expertise: Molecular bacteriology; transcriptional profiling; host-pathogen interactions

Research areas: Tuberculosis drug discovery; mycobacterial pathogenesis; TB biomarkers

Read about the TB research team at BSMS >

Biography

Dr Simon Waddell trained in molecular microbiology at the University of Birmingham before completing a PhD in mycobacterial pathogenicity at St Georges, University of London. He then spent a stint as a postdoctoral scientist at Stanford University profiling host responses to infection. He joined BSMS in 2010. His work focuses on understanding the interactions between host and pathogen, and investigating the action of anti-mycobacterial compounds through drug therapy. He has published in high impact journals such as Science, PLoS Medicine, BMC Medicine, Cell Host & Microbe, American Journal of Respiratory and Critical Care Medicine, Genome Biology, Journal of Clinical Investigation and Nature Communications.

His ORCID ID is orcid.org/0000-0002-3684-9116;
ResearchGate ID is https://www.researchgate.net/profile/Simon_Waddell.
Full list of publications available at Sussex Research Online (SRO) 

Research

Over 10 million people caught tuberculosis (TB) in 2015 and 1.8 million people died of the disease. Globally more than 2 billion people are infected with the causative agent, Mycobacterium tuberculosis. TB remains one of the top 10 causes of death worldwide.

The standard drug therapy for TB uses combinations of 4 drugs over 6 months. The recommended treatment for multidrug-resistant TB lasts 18–24 months or more, with increasingly toxic combinations of second-line drugs. New drug regimens are needed to maintain and improve therapy for tuberculosis, shortening treatment duration and targeting drug-resistant bacteria.

The Waddell lab uses genome-wide technologies to understand TB drug action during human disease, to define M.tuberculosis populations that survive early drug therapy, and to identify the mode of action of novel anti-mycobacterial compounds. Our research also explores the interactions between host and pathogen throughout the disease process using transcriptional signatures derived from immune cells and M.tuberculosis to better explain TB pathogenicity and to reveal novel treatment strategies.

Teaching

Simon teaches in Years 1-4 of the BM-BS medical degree at BSMS and contributes to the MSc in Global Health. He lectures genome biology and infectious diseases and runs student-selected components. He is module leader for BSMS 404 ‘4th Year Independent Research Project’. He is also an academic tutor. He supervises BSc project students, medical students and PhD research projects.

Selected publications

Castañeda-García, A, AI Prieto, J Rodríguez-Beltrán et al. (2017) A non-canonical mismatch repair pathway in prokaryotes. Nature Communications; 8, 14246.

Honeyborne, I, TD McHugh, I Kuittinen, A Cichonska, D Evangelopoulos, K Ronacher, PD van Helden, SH Gillespie, D Fernandez-Reyes, G Walzl, J Rousu, PD Butcher and SJ Waddell (2016). Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy. BMC Med; 14(1):68.

Evangelopoulos, D, J Diniz da Fonsceca and SJ Waddell (2015). Understanding anti-tuberculosis drug efficacy: rethinking bacterial populations and how we model them. International Journal of Infectious Diseases; 32:76-80.

Waddell, SJ, EG Salina, N Hoffmann, I Rosenkrands, PD Butcher, AS Kaprelyants (2014). Potassium availability triggers Mycobacterium tuberculosis transition to, and resuscitation from, non-culturable (dormant) states. Open Biology; 4(10) pii: 140106.

Waddell, SJ, O Turapov, B Burke, S Glenn, AA Sarybaeva, G Tudo, G Labesse, DI Young, M Young , PW Andrew, PD Butcher, M Cohen-Gonsaud, GV Mukamolova (2014). Oleoyl coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in mycobacteria. Journal of Biological Chemistry; 289(36): 25241-9.

Waddell, SJ, O Turapov, B Burke, S Glenn, A Sarybaeva, G Tudo, G Labesse, DI Young, M Young, PW Andrew, PD Butcher, M Cohen-Gonsaud, GV Mukamolova (2014). Antimicrobial treatment improves mycobacterial survival in non-permissive growth conditions. Antimicrobial Agents and Chemotherapy; 58(5): 2798-806.

Waddell, SJ, A von Kamp, S Klamt and O Neyrolles (2013). Host-Pathogen Interactions, in Systems Biology of Tuberculosis (JJ Mcfadden, ed.), Springer; 107-126.

Tudo, G, K Laing, DA Mitchison, PD Butcher and SJ Waddell (2010). Examining the basis of isoniazid tolerance in non-replicating Mycobacterium tuberculosis using transcriptional profiling. Future Medicinal Chemistry; 2(8): 1371-1383.

Waddell, SJ, SJ Popper, KH Rubins, MJ Griffiths, PO Brown, M Levin and DA Relman (2010). Dissecting interferon-induced transcriptional programs in human peripheral blood cells. PLoS ONE; 5(3): e9753.

Makarov, V, G Manina, K Mikusova et al. (2009). Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis. Science; 324(5928): 801-4. 

Waddell, SJ, NJ Garton, AL Sherratt, S-M Lee, RJ Smith, C Senner, J Hinds, K Rajakumar, RA Adegbola, GS Besra, PD Butcher and MR Barer (2008). Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum. PLoS Medicine; 5(4): e75. 

Waddell, SJ, L Tailleux1, M Pelizzola, A Mortellaro, M Withers, A Tanne, PR Castagnoli, B Gicquel, NG Stoker, PD Butcher, M Foti and O Neyrolles (2008). Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages. PLoS ONE; 3(1): e1403.

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