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Brighton & Sussex Medical School

Haematology Research Group

BSMS > Research > Clinical and experimental medicine > Oncology > Haematology-Research-Group

Haematology Research Group

The Haematology Research Group is a network of seven labs across the School of Life Sciences at the University of Sussex and Brighton and Sussex Medical School. The researchers involved have shared interests in the molecular mechanisms active in normal and malignant haematology (the branch of medicine involving study and treatment of the blood). The broad remit of the Haematology Research Group is to increase understanding of the molecular changes that occur in blood cancers, with the ultimate aim of designing novel and effective therapies.
Taking a sample of blood from a test tube

Overview

The network adopts a range of translational, computational and biochemical approaches in the laboratory, to investigate the molecular mechanisms driving blood cancer. The group pools resources and ideas, to not only foster closer collaboration between the two Schools involved, but also University Hospitals Sussex NHS Foundation Trust to maximise translational impact of research for patients.

In addition to laboratory based research, the group hosts vibrant and engaging seminar sessions to share and discuss research findings with the aim of training and inspiring the next generation of haematology scientists and doctors. Please consult Meet the team below to learn about specific research interests.

Abstract microscope image showing blood plasma

Research publications

Christopher Parker, Adam C Chambers, Dustin J Flanagan, Ho JWY, Tracey J Collard, Greg Ngo, Duncan M Baird, Penny Timms, Rhys G Morgan, Owen J Sansom, Ann C Williams. BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination. DNA Repair (Amst). 2022 Apr 16;115:103331. doi: 10.1016/j.dnarep.2022.103331.\

Wagstaff, Megan, Tsaponina, Olga, Caalim, Gilian, Greenfield, Hayley, Milton-Harris, Leanne, Mancini, Erika J, Blair, Allison, Heesom, Kate J, Tonks, Alex, Darley, Richard L, Roberts, Stefan G and Morgan, Rhys G (2022) Crosstalk between β-catenin and WT1 signalling activity in acute myeloid leukemia. Haematologica. ISSN 0390-6078

Wagstaff, Megan, Coke, Brandon, Hodgkiss, Georgia R and Morgan, Rhys G (2022) Targeting β-catenin in acute myeloid leukaemia: past, present, and future perspectives. Bioscience Reports. ISSN 0144-8463

Menendez-Gonzalez, Juan Bautista, Sinnadurai, Samantha, Gibbs, Alex, Thomas, Leigh-anne, Konstantinou, Maria, Garcia-Valverde, Alfonso, Boyer, Magali, Wang, Zhengke, Boyd, Ashleigh S, Blair, Allison, Morgan, Rhys G and Rodrigues, Neil P (2019) Inhibition of GATA2 restrains cell proliferation and enhances apoptosis and chemotherapy mediated apoptosis in human GATA2 overexpressing AML cells. Scientific Reports, 9 (1). a12212. ISSN 2045-2322

Escudero, Laura, Cleal, Kez, Ashelford, Kevin, Fegan, Chris, Pepper, Chris, Liddiard, Kate and Baird, Duncan M (2019). Telomere fusions associate with coding sequence and copy number alterations in CLL. Leukemia. ISSN 0887-6924

Norris, Kevin, Hillmen, Peter, Rawstron, Andrew, Hills, Robert, Baird, Duncan M, Fegan, Christopher D and Pepper, Chris (2019) Telomere length predicts for outcome to FCR chemotherapy in CLL. Leukemia. ISSN 0887-6924

Corcoran, David B, Lewis, Thomas, Nahar, Kazi S, Jamshidi, Shirin, Fegan, Christopher, Pepper, Chris, Thurston, David Eand Rahman, Khondaker Miraz (2019) Effects of systematic shortening of noncovalent C8 side chain on the cytotoxicity and NF-κB inhibitory capacity of pyrrolobenzodiazepines (PBDs). Journal of Medicinal Chemistry, 62 (4). pp. 2127-2139. ISSN 0022-2623

Morgan, Rhys G, Ridsdale, Jenna, Payne, Megan, Heesom, Kate J, Wilson, Marieangela C, Davidson, Andrew, Greenhough, Alexander, Davies, Sara, Williams, Ann C, Blair, Allison, Waterman, Marian L, Tonks, Alex and Darley, Richard L (2019) LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells. Haematologica. ISSN 1592-8721

Graham, Charlotte, Jozwik, Agnieszka, Pepper, Andrea and Benjamin, Reuben (2018) Allogeneic CAR-T cells: more than ease of access? Cells, 7 (10). p. 155. ISSN 2073-4409

Mele, Sylvia, Devereux, Stephen, Pepper, Andrea G, Infante, Elvira and Ridley, Anne J (2018) Calcium-RasGRP2-Rap1 signaling mediates CD38-induced migration of chronic lymphocytic leukemia cells. Blood Advances, 2 (13). pp. 1551-1561. ISSN 2473-9529

Ngo, Greg, Hyatt, Sam, Grimstead, Julia, Jones, Rhiannon, Hendrickson, Eric, Pepper, Chris and Baird, Duncan (2018)PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation. Oncotarget, 9 (101). pp. 37549-37563. ISSN 1949-2553

more Publications from the HRG >

4 members of the HRG group

Work with us

The Haematology Research Group is a committed training centre for PhD students, Postdoctoral and Clinical Research Fellows in the field of haematology and will support early career researchers in joining the network in the future.

The network is currently seeking expressions of interest from prospective clinical research fellows who are both interested and motivated to undertake research studies in the field of blood cancer. Please use the contact details below or for individual members for all enquiries.