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4 members of the HRG group
Brighton & Sussex Medical School

Meet the team

Dr Tim Chevassut headshot

Dr Tim Chevassut
Senior Lecturer in Haematology

Dr Chevassut is a clinical haematologist whose research programme is focussed primarily on understanding acute myeloid leukaemia and myelodysplasia with a particular interest in DNA methylation and epigenetic therapy. The research is translational bench-to-bedside with the goal of bringing better treatments to patients through improved understanding of disease biology. Dr Chevassut’s research laboratory is located in the BSMS Medical Research Building on the University of Sussex campus with strong links to the clinical service and clinical trials unit at the Royal Sussex County Hospital in Brighton.

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Dr Erika Mancini Headshot

Dr Erika Mancini
Reader in Biomedical Structural Biology (Biochemistry)

Erika's research seeks to understand at the molecular level the specific protein-protein and protein-DNA interactions involved in the regulation of haematopoiesis by transcription factor complexes. Insights into the deregulation of these complexes in Leukaemia helps Erika to contribute to the design of novel targeted therapies. She is particularly interested in transcription factors involved in T-cell acute lymphoblastic leukaemia (T-ALL) and Multiple Myeloma (MM).

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Dr Simon Mitchell Headshot

Dr Simon Mitchell
Lecturer in Cancer Research listing text

Simon’s primary research focus is in understanding how intracellular, molecular signalling networks control immune cell fate, and how misregulation of these molecular networks lead to haematological malignancies. His combination of immunology and haematological training lead to a particular interest in B-cell lymphomas. 

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Dr Rhys Morgan Headshot

Dr Rhys Morgan
Lecturer in Biomedical Science (Biochemistry)

Rhys' research seeks to investigate the role of a signal transduction pathway, Wnt/β-catenin signalling, in both normal blood development and haematological malignancy. Ultimately, Rhys is seeking to understand how this cell signalling pathway converts normal healthy blood cells into 'faulty' leukaemia cells, and develop novel therapeutic strategies for patients. His research is focused on one particularly aggressive blood cancer called acute myeloid leukaemia (AML).

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Dr Andrea Pepper Headshot

Dr Andrea Pepper
Reader in Cancer Research

The focus of Andrea's research has been on the effect of the microenvironment on tumour proliferation and survival. This work has built on the main finding of her PhD, which was that the successful elimination of a tumour requires looking beyond the tumour itself to the effects of the surrounding microenvironment.

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Professor Chris Pepper Headshot

Professor Chris Pepper
Professor in Cancer Studies

For more than two decades, Chris’ research has focused on understanding the mechanisms that underpin the development of disease progression and drug resistance using primary chronic lymphocytic leukaemia (CLL) cells as a model. Chris maintains that the study of this disseminated tumour represents an unrivalled opportunity to unravel these processes as longitudinal sampling from both the lymphoid tissues and the peripheral blood is possible.

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Professor Michelle West Headshot

Professor Michelle West
Professor of Tumour Virology (Biochemistry) 

Michelle’s research investigates how the cancer-associated Epstein-Barr virus (EBV) drives lymphoma development. EBV is associated with the development of Burkitt’s, Hodgkin’s, post-transplant and certain T-cell and natural killer cell lymphomas. The virus infects normal short-lived B lymphocytes and immortalises them by altering the expression of cell growth and survival genes. Michelle’s research examines the molecular mechanisms of immortalisation and gene regulation by EBV proteins and is focussed on long-range transcriptional and epigenetic control and cell cycle deregulation.

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