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Dr Chris Jones

Chris Jones (2) web

Dr Chris Jones

Research Fellow in Medical Statistics
E: C.I.Jones@bsms.ac.uk
T: +44 (0)1273 644587
Location: Watson Building, University of Brighton, Falmer, BN1 9PS

Areas of expertise: Bioinformatics; biomarkers; biostatistics; cancer (human disease); cancer cell biology; cell cultures; data analysis; drosophila; gene regulation; genetics and development; miRNA; molecular biology; mRNA; next-generation sequencing; non-coding RNA; RNA stability; RNA-seq; RNAi; statistics; statistics for clinical trials

Biography

Chris received a BSc in Biochemistry from the University of Sussex in 2007, followed by a PhD from Brighton and Sussex Medical School in 2011. His PhD and subsequent post-doctoral work in the lab of Prof. Sarah Newbury, using the model organism Drosophila melanogaster, focused on post-transcriptional gene regulation at the level of mRNA by the 5'-3' exoribonuclease XRN1 (Pacman). This work involved microarray, RNA-sequencing and qRT-PCR profiling of mRNAs and miRNAs in developing Drosophila tissues and identified potential targets of XRN1.

Chris initiated a new project in 2015 based on the observation that XRN1 expression is suppressed in the human bone cancer osteosarcoma, with funding from the Brighton University Rising Stars Initiative and the University of Sussex Research Development Fund. This work used qRT-PCR and siRNA approaches in human osteosarcoma cell lines and Chris now co-supervises a PhD student working on the project.

In September 2015, Chris moved to the position of Research Fellow in Medical Statistics at BSMS, working with Dr. Stephen Bremner to provide statistical support to BSMS, Brighton and Sussex University Hospitals NHS Trust and Clinical Trials Unit researchers, and has been involved in over 40 studies and trials since 2015. Chris completed a BA in Mathematics and Statistics from the Open University in 2017 and achieved Chartered Statistician (CStat) status through the Royal Statistical Society in April 2019.

Chris continues to be involved with lab research as holds a BBSRC grant as a Co-I with Prof. Sarah Newbury and Prof. Simon Morley on understanding the cellular pathways regulated by Dis3L2 in cell proliferation, using Drosophila as a model organism. This grant funds a post-doctoral researcher, lab technician and PhD student.

Research

Chris is primarily interested in statistical approaches to the design and analysis of quantitative research. Particularly for Clinical trials and lab based research.

Chris has a lab background, and a strong interest and extensive experience in whole-genome approaches to gene expression analysis, such as RNA-sequencing, microarrays and qRT-PCR arrays. He also has extensive experience in the design of experiments utilising molecular biology and cell culture techniques.

Selected publications

Jack, James M, Ellicott, Helen, Jones, Christopher I, Bremner, Stephen A, Densham, Ian and Harper, C Mark (2019)Determining the accuracy of zero-flux and ingestible thermometers in the peri-operative setting. Journal of Clinical Monitoring and Computing. ISSN 1387-1307

Middleton, Jo, Cassell, Jackie, Jones, Chris, Lanza, Stefania, Head, Michael G and Walker, Stephen L (2018) Authors reply to ‘Scabies control: the forgotten role of personal hygiene’, correspondence by Duncan Mara. The Lancet Infectious Diseases, 18 (10). pp. 1068-1069. ISSN 1473-3099

Cassell, Jackie A, Middleton, Jo, Nalabanda, Ananth, Lanza, Stefania, Head, Michael G, Bostock, Jennifer, Hewitt, Kirsty, Jones, Christopher Ian, Darley, Charles, Karir, Simran and Walker, Stephen L (2018) Scabies outbreaks in ten care homes for elderly people: a prospective study of clinical features, epidemiology, and treatment outcomes. The Lancet Infectious Diseases. ISSN 1473-3099

Edelman, N L, Cassell, J A, Mercer, C H, Bremner, S A, Jones, Chris, Gersten, A and deVisser, R O (2018) Deriving a clinical prediction rule to target sexual healthcare to women attending British General Practices. Preventive Medicine, 112. pp. 185-192. ISSN 0091-7435

Osborne, G E C, Appleyard, S A, Gilbert, D C, Jones, C I, Villanueva, M, Peasgood, E, Robinson, A, Nikapota, A and Ring, A (2017) Comprehensive geriatric assessment in men aged 70 years or older with localised prostate cancer undergoing radical radiotherapy. Clinical Oncology, 29 (9). pp. 609-616. ISSN 0936-6555

Behar, Laura, Chadwick, David, Dunne, Angela, Jones, Christopher I, Procter, Clare, Rajkumar, Chakravarthi, Sharratt, Paula, Stanley, Philip, Whiley, Angela, Wilks, Mark and Llewelyn, Martin J (2017) Toxigenic Clostridium difficile colonization among hospitalised adults; risk factors and impact on survival. Journal of Infection, 75 (1). pp. 20-25. ISSN 01634453

Savage, P, Holloway, C, Lindsay, G, Shubrook, K, Jones, C, Fung, M, Schaff, K, Anderson, H, Nystedt, K and Rauw, J(2016) Cancer referral and treatment activity 2010–2015: a population-based study from Vancouver Island. Current Oncology, 23 (6). e626-e629. ISSN 1198-0052

Pashler, Amy L, Towler, Ben, Jones, Christopher I and Newbury, Sarah F (2016) The roles of the exoribonucleases DIS3L2 and XRN1 in disease. Biochemical Society Transactions, 44 (5). pp. 1377-1384. ISSN 0300-5127

Whale, Richard, Harris, Michael, Kavanagh, Gail, Wickramasinghe, Vijitha, Jones, Chris, Marwaha, Steven, Jethwa, Ketan, Ayadurai, Nirmalan and Thompson, Andrew (2016) Effectiveness of antipsychotics used in first-episode psychosis: a naturalistic cohort study. BJPsych Open, 2 (5). pp. 323-329. ISSN 2056-4724

Towler, Benjamin P, Jones, Christopher L, Harper, Kirsty L, Waldron, Joseph A and Newbury, Sarah F (2016) A novel role for the 3′-5′ exoribonuclease Dis3L2 in controlling cell proliferation and tissue growth. RNA Biology, 13 (12). pp. 1286-1299. ISSN 1547-6286

Jones, Christopher I, Pashler, Amy L, Towler, Benjamin P, Robinson, Sophie R and Newbury, Sarah F (2016) RNA-seq reveals post-transcriptional regulation of Drosophila insulin-like peptide dilp8 and the neuropeptide-like precursor Nplp2 by the exoribonuclease Pacman/XRN1. Nucleic Acids Research, 44 (1). pp. 267-280. ISSN 0305-1048 

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