Barriers and facilitators to the development of precision medicine in asthma-related disease in children and young people
Prof Somnath Mukhopadhyay, Dr Elaney Youssef Application
Tuesday 13 July 2021
About the Project
Applications are invited for a 3-year PhD studentship to join the Clinical and Experimental Medicine department at Brighton and Sussex Medical School.
Asthma and eczema are common in childhood. In the UK, asthma affects one in 11 children and eczema affects one in five (1). Despite high standards of healthcare driven by NICE guidance, many children still suffer from poorly controlled asthma (2-4) which results in reduced quality of life and increased demands on healthcare services(5). There is evidence to suggest significant overlap between these conditions (6) arising from particular phenotypes (7, 8). As a result, the development of personalised treatment strategies may be effective in managing these conditions.
The project aims to identify the barriers and facilitators to the development of precision medicine for managing asthma, eczema, allergy and upper airway disease for children and young people. More specifically, the student will develop an understanding of the clinical science, including biology, by reviewing the relevant literature and performing focussed reviews to address gaps in knowledge; and will develop an understanding of the barriers and facilitators to the process of introducing precision medicine-linked treatment strategies to this area of medical practice.
This project offers a range of training opportunities and the student will acquire essential skills from a variety of areas including clinical science, health services research, systematic reviews and qualitative methods. This should provide the successful candidate with critical skills and substantial experience to make them a highly competitive candidate for a postdoctoral research position.
Funding NotesApplicants for this 3-year studentship starting in October 2021 should possess a minimum of a First or Upper Second Class Honours degree (or equivalent) in Nursing, Pharmacy, Medicine, Health Sciences, Psychology or similar. Informal enquiries should be direct to Prof Somnath Mukhopadhyay (email@example.com). In order to apply please visit the University of Brighton website. Please contact the BSMS Doctoral and Research Officer (firstname.lastname@example.org) with any queries.
1. Asthma UK. Asthma facts and statistics 2021 [Available from: www.asthma.org.uk/about/media/facts-and-statistics.]
2. Lo DK, Beardsmore CS, Roland D, Richardson M, Yang Y, Danvers L, et al. Lung function and asthma control in school-age children managed in UK primary care: a cohort study. Thorax. 2020;75(2):101-7.
3. Harris K, Mosler G, Williams S, Whitehouse A, Raine R, Grigg J. Asthma control in London secondary school children. J Asthma. 2017;54(10):1033-40.
4. Levy M. Risks of poor asthma outcome in 14,405 children and young people in London. NPJ Prim Care Respir Med. 2021;31(1):3.
5. Nunes C, Pereira A, Morais-Almeida M. Asthma costs and social impact. Asthma Res Pract. 2017;3:1.
6. Palmer C, Irvine A, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee S, et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet. 2006;38(4):441-6.
7. Kuruvilla M, Lee F, Lee G. Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease. Clin Rev Allergy Immunol. 2019;56(2):219-33.
8. Holgate S, Walker S, West B, Boycott K. The Future of Asthma Care: Personalized Asthma Treatment. Clin Chest Med. 2019;40(1):227-41.