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Dr Tom Ruffles

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Dr Tom Ruffles (MBBS MRCPCH BSc)

Clinical Senior Lecturer in Paediatric Respiratory Medicine and Honorary Consultant in Paediatric Respiratory Medicine
T: 01273 696955 (x62520)
Location: Level 6, The Royal Alexandra Children's Hospital, Eastern Road, Brighton, BN2 5BE

PA: Katie Isaac
: 01273 696955 (x2409)

Areas of expertise: Paediatric Respiratory Medicine

Research areas: Asthma, protracted bacterial bronchitis

Other relevant positions: Lead for Long-term Conditions module of MSc in Paediatrics



Dr Tom Ruffles graduated from St George’s University of London in 2008 and completed his paediatric specialty training through the Kent, Surrey and Sussex deanery and undertook a two-year paediatric respiratory fellowship at the Queensland Children’s Hospital in Brisbane, Australia. In August 2019 he was appointed Senior Clinical fellow at Brighton and Sussex Medical School and Honorary Consultant in Paediatric Respiratory Medicine at Brighton and Sussex University Hospital NHS Trust.


Dr Ruffles, primary research interests are in relation to the management of chronic cough in children and personalised medicine prescribing in young people’s asthma. He is collaborating with researchers from Brighton and Sussex Medical School, The University of Dundee and The Queensland Children’s Hospital.



Dr Ruffles is lead for the Long-term Conditions module of the MSc in Paediatrics. He teaches in the Paediatric Modules of the BSMS curriculum and takes part in OSCE examinations.

Selected Publications

Ruffles T, Inglis SK, Bremner S, Rabe H, Memon A, Seddon P, Basu K, Bremner S, Rabe H, Tavendale R, Palmer CN, Mukhopadhyay S, Fidler K. Environmental risk factors for respiratory infection and wheeze in young children: a multi-centre birth cohort study.

Ruffles T, Basu K, Inglis SK, Bremner S, Rabe H, Memon A, Seddon P, Tavendale R, Palmer CN, Mukhopadhyay S, Fidler K. Mannose‐binding lectin genotype is associated with respiratory disease in young children: A multicenter cohort study. Pediatric Pulmonology. 2022 Nov;57(11):2824-33.

Ruffles T, Jones CJ, Palmer C, Turner S, Grigg J, Tavendale R, Hogarth F, Rauchhaus P, Pilvinyte K, Hannah R, Smith H. Asthma prescribing according to Arg16Gly beta-2 genotype: a randomised trial in adolescents. European Respiratory Journal. 2021 Aug 1;58(2).

Ruffles TJ, Marchant JM, Masters IB, Yerkovich ST, Wurzel DF, Gibson PG, Busch G, Baines KJ, Simpson JL, Smith‐Vaughan HC, Pizzutto SJ. Outcomes of protracted bacterial bronchitis in children: A 5‐year prospective cohort study. Respirology. 2021 Mar;26(3):241-8.

Ruffles TJ, Goyal V, Marchant JM, Masters IB, Yerkovich S, Buntain H, Cook A, Schultz A, Upham JW, Champion A, Versteegh L. Duration of amoxicillin-clavulanate for protracted bacterial bronchitis in children (DACS): a multi-centre, double blind, randomised controlled trial. The Lancet Respiratory Medicine. 2021 Oct 1;9(10):1121-9.

Nontuberculous Mycobacterium. Chapter in Cystic Fibrosis: a multi-organ systems approach. Springer Nature. 1st Edition. Tom JC Ruffles & Claire Wainwright. July 2020.

Osteogenic Sarcoma in an adolescent with Cystic Fibrosis: Successful treatment despite significant obstacles. Ruffles T, Black R, Nicholls W, Laing B, Isles A. Frontiers in Pediatrics. 2018 Sep 21;6:245.

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