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Dr Yoko Nagai

Yoko Nagai

Dr Yoko Nagai (BSc, PhD)

Wellcome Trust Research Fellow
T: +44 (0)1273 876828
Location: Clinical Imaging Sciences Centre (CISC), University of Sussex, Brighton, BN1 9RR

Areas of expertise: Clinical Neuroscience and Applied psychology, Brain-Body interaction, Biofeedback
Research areas: Role of autonomic function in epilepsy, Biofeedback treatment on neurological and psychiatric conditions, Social anxiety in Japanese young adults (Hikikomori)
Other website: - Proven Therapy for Drug-Resistant Epilepsy: Online biofeedback therapy for epilepsy based on cutting-edge neuroscientific research.



Dr Yoko Nagai is a translational neuroscientist with interests in mind-body interaction and human consciousness. Her PhD at the Institute of Psychiatry, King's College London, involved the investigation and development of a non-drug therapy for patients with drug-resistant epilepsy. The therapy is now termed as Autonomic Cognitive Rehabituation training (ACRT). This pioneering work attracted funding for a clinical trial at the Institute of Neurology, UCL, where she conducted six years of postdoctoral research.

She also undertook several neuroimaging studies to investigate the neural mechanisms of ACRT. She was appointed as a lecturer at the University of Essex in 2007 and held this position until 2010. She started a post at the Brighton and Sussex Medical School in 2009 and is currently funded by the Wellcome Trust.


Dr Nagai's EPILEPSY TREATMENT on BBC South East Today


Nagai Y. Modulation of autonomic activity in neurological conditions: epilepsy and Tourette Syndrome. Frontiers Autonomic Neuroscience. 2015, volume9, article 278

Nagai Y and Trimble MR. Long-term effects of electrodermal biofeedback training on seizure control in patients with drug-resistant epilepsy: Two case reports. Epilepsy Research, 2014, 108: 149-52.

Nagai Y, Cavanna AE, Critchley HD, Stern JS, Robertson MM, Joyce EM. Biofeedback treatment for Tourette Syndrome: Preliminary randomized controlled trial. Cogn Behav Neurol. 2014, 27:17-24.

Nagai Y and Trimble MR, Biofeedback treatment and seizure control. In Mostfsky D (Ed), Hand book of Behavioural Medichine. Wiley-Blackwell, 2014, 149-152.

Nagai Y. Biofeedback and epilepsy. Curr Neurol Neurosci Rep, 2011, 11, 433-450.

Nagai Y, Critchley HD, Rothwell JC, Duncan JS, Trimble MR. Changes in cortical potential associated with modulation of peripheral sympathetic activity in patients with epilepsy. Psychosomatic Medicine 2009, 71: 84-92.

Nagai Y, Goldstein LH, Fenwick PBC, Trimble MR.  Clinical efficacy of biofeedback treatment on reducing seizures in adult epilepsy: a preliminary randomized controlled study. Epilepsy & Behaviour 2004, Vol 5/2: 216-223.

Nagai Y, Critchley HD, Featherstone E, Fenwick PBC, Trimble MR, Dolan RJ. Brain activity relating to the Contingent Negative Variation (CNV): fMRI investigation. Neuroimage 2004, 21:1232-1241.

Nagai Y, Critchley HD, Featherstone E, Trimble MR, Dolan RJ. Activity in ventromedial prefrontal cortex covaries with sympathetic skin conductance level (SCL): a physiological account of a “default mode” of brain function. Neuroimage 2004, 22:243-251.

Nagai Y, Goldstein LH, Critchley HD, Fenwick PBC. Influence of sympathetic autonomic arousal on contingent negative variation: implications for a therapeutic behavioural intervention in epilepsy. Epilepsy Res 2004, 58:185-193.