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BSMS > About BSMS > Contact us > Staff > Professor Martin Llewelyn

Professor Martin Llewelyn

AMR Researchers - Dr Martin Llewelyn

Professor Martin Llewelyn (BSc, FRCP, DTMH, PhD)

Professor in Infectious Diseases
E: M.J.Llewelyn@bsms.ac.uk
T: +44 (0)1273 876671
Location: Medical Research Building, Room 1.08, BSMS, University of Sussex, BN1 9PS

PA: Sandy E Gray
T: +44 (0)1273 877017
E: s.gray@bsms.ac.uk

DA: Debbie Miller
T: +44 (0)1273 877890
E: d.miller@bsms.ac.uk

Areas of expertise: Healthcare associated infection; antimicrobial resistance
Research areas: Infection and immunology

Biography

Prof Martin Llewelyn has worked at BSMS since 2004 and holds an honorary contract at Brighton and Sussex University Hospitals NHS Trust as a Consultant in Infectious Diseases. He did his Undergraduate medical training at the Royal London Hospital graduating in 1992. After Medical House-Officer and Senior House Officer posts in North East London he undertook higher specialist training in Infectious Diseases and General Internal Medicine in North Thames. He spent three years on an MRC-funded research training fellowship at Imperial College studying host immune responses to bacterial superantigen toxins. He obtained his CCT and PhD in 2004. 

Research

Martin’s research is focused on the common, life-threatening infections which affect patients in the NHS, in particular on healthcare associated and antibiotic resistant pathogens such as Staphylococcus aureus and Clostridium difficile. Major current themes of his research are application of microbial genome sequencing to the study of transmission and pathogenesis of S. aureus infection and reducing antibiotic usage in hospital through optimising treatment strategies. Martin’s research is undertaken in collaboration with groups such as Modernising Medical Microbiology, the International Staphylococcus Aureus Collaboration and the NIHR-funded Antibiotic Reduction and Conservation in Hospitals (ARK-Hospital) programme.

Teaching

Martin teaches extensively on the Undergraduate Course at BSMS in Clinical Infectious Diseases, Microbiology and Immunology. In the first term of Year 1 ‘Foundations of Health and Disease’ he teaches basic microbiology and about the role of the host and pathogen in the outcome of infection. In Year 3 he teaches about the scientific basis of infectious diseases and the immune response to infection. In the Fourth Year specialist rotation in infectious diseases he teaches the diagnosis and management of common infectious diseases. Each year Martin supervises medical students undertaking both clinical and laboratory based individual research projects.

Selected publications

Onakpoya IJ, Walker AS, Tan PS, Spencer EA, Gbinigie OA, Cook J, Llewelyn MJ,Butler CC. Overview of systematic reviews assessing the evidence for shorterversus longer duration antibiotic treatment for bacterial infections in secondarycare. PLoS One. 2018 Mar 28;13(3):e0194858. doi: 10.1371/journal.pone.0194858.eCollection 2018. Review. PubMed PMID: 29590188; PubMed Central PMCID:PMC5874047.  

Islam J, Ashiru-Oredope D, Budd E, Howard P, Walker AS, Hopkins S, LlewelynMJ. A national quality incentive scheme to reduce antibiotic overuse inhospitals: evaluation of perceptions and impact. J Antimicrob Chemother. 2018 Jun1;73(6):1708-1713. doi: 10.1093/jac/dky041. PubMed PMID: 29506043.  

Young BC, Wu CH, Gordon NC, Cole K, Price JR, Liu E, Sheppard AE, Perera S,Charlesworth J, Golubchik T, Iqbal Z, Bowden R, Massey RC, Paul J, Crook DW, PetoTE, Walker AS, Llewelyn MJ, Wyllie DH, Wilson DJ. Severe infections emerge fromcommensal bacteria by adaptive evolution. Elife. 2017 Dec 19;6. pii: e30637. doi:10.7554/eLife.30637. PubMed PMID: 29256859; PubMed Central PMCID: PMC5736351.  

Thwaites GE, Scarborough M, Szubert A, Nsutebu E, Tilley R, Greig J, WyllieSA, Wilson P, Auckland C, Cairns J, Ward D, Lal P, Guleri A, Jenkins N, Sutton J,Wiselka M, Armando GR, Graham C, Chadwick PR, Barlow G, Gordon NC, Young B, Meisner S, McWhinney P, Price DA, Harvey D, Nayar D, Jeyaratnam D, Planche T, Minton J, Hudson F, Hopkins S, Williams J, Török ME, Llewelyn MJ, Edgeworth JD,Walker AS; United Kingdom Clinical Infection Research Group (UKCIRG). Adjunctiverifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre,randomised, double-blind, placebo-controlled trial. Lancet. 2018 Feb17;391(10121):668-678. doi: 10.1016/S0140-6736(17)32456-X. Epub 2017 Dec 14.PubMed PMID: 29249276; PubMed Central PMCID: PMC5820409.  

Llewelyn MJ, Fitzpatrick JM, Darwin E, SarahTonkin-Crine, Gorton C, Paul J,Peto TEA, Yardley L, Hopkins S, Walker AS. The antibiotic course has had its day.BMJ. 2017 Jul 26;358:j3418. doi: 10.1136/bmj.j3418. PubMed PMID: 28747365.  

Caserta S, Mengozzi M, Kern F, Newbury SF, Ghezzi P, Llewelyn MJ. Severity ofSystemic Inflammatory Response Syndrome Affects the Blood Levels of CirculatingInflammatory-Relevant MicroRNAs. Front Immunol. 2018 Feb 5;8:1977. doi:10.3389/fimmu.2017.01977. eCollection 2017. PubMed PMID: 29459855; PubMed CentralPMCID: PMC5807656.

Gordon, N C, Pichon, B, Golubchik, T, Wilson, D J, Paul, J, Blanc, D S, Cole, K, Collins, J, Cortes, N, Cubbon, M, Gould, F K, Jenks, P J, Llewelyn, M, Nash, J Q, Orendi, J M, Paranthaman, K, Price, J, Senn, L, Thomas, H L, Wyllie, S, Crook, D W, Peto, T E A, Walker, A S and Kearns, A M (2017) Whole genome sequencing reveals the contribution of long-term carriers in Staphylococcus aureus outbreak investigation. Journal of Clinical Microbiology. ISSN 0095-1137.

Behar, Laura, Chadwick, David, Dunne, Angela, Jones, Christopher I, Procter, Clare, Rajkumar, Chakravarthi, Sharratt, Paula, Stanley, Philip, Whiley, Angela, Wilks, Mark and Llewelyn, Martin J (2017) Toxigenic Clostridium difficile colonization among hospitalised adults; risk factors and impact on survival. Journal of Infection. ISSN 01634453.

Ledda, Alice, Price, James R, Cole, Kevin, Llewelyn, Martin J, Kearns, Angela M, Crook, Derrick W, Paul, John and Didelot, Xavier (2017) Re-emergence of methicillin susceptibility in a resistant lineage of Staphylococcus aureus. Journal of Antimicrobial Chemotherapy. dkw570. ISSN 0305-7453.

Price, James R, Cole, Kevin, Bexley, Andrew, Kostiou, Vasiliki, Eyre, David W, Golubchik, Tanya, Wilson, Daniel J, Crook, Derrick W, Walker, A Sarah, Peto, Timothy E A, Llewelyn, Martin J and Paul, John (2017) Transmission of Staphylococcus aureus between health-care workers, the environment, and patients in an intensive care unit: a longitudinal cohort study based on whole-genome sequencing. Lancet Infectious Diseases, 17 (2). pp. 207-214. ISSN 1473-3099.