Publications
TLR1/2 and 5 induce elevated cytokine levels from rheumatoid arthritis monocytes independent of ACPA or RF autoantibody status. Ryan S. Thwaites, Sarah Unterberger, Giselle Chamberlain, Karen Walker-Bone, Kevin. A. Davies & Sandra Sacre. Rheumatology, 2020 (In Press).
Structural modification of the antidepressant mianserin reveals that its anti-inflammatory activity is independent of 5-hydroxytryptamine receptors. Sandra Sacre, Albert Jaxa-Chamiec, Caroline Low, Giselle Chamberlain, Cathy Tralau-Stewart. Front Immunol. 2019; May 24; 10:1167
Precipitation of Soluble Uric Acid is Necessary for in vitro Activation of the NLRP3 Inflammasome in Primary Human Monocytes. Alberts, Ben; Barber, James; Sacre, Sandra; Davies, Kevin; Ghezzi, Pietro; Mullen, Lisa. J Rheumatol. 2019; 46 (9), 1141-1150
Oligodeoxynucleotide inhibition of Toll-like receptors 3, 7, 8 and 9 suppresses cytokine production in a human rheumatoid arthritis model. Sacre S., Lo A., Gregory B., Stephens M., Chamberlain G., Stott, P. and Brennan F. Eur J Immunol. 2016; Mar;46(3):772-781.
Simvastatin inhibits TLR8 signaling in primary human monocytes and spontaneous TNF production from rheumatoid synovial membrane cultures. Mullen L, Ferdjani J, Sacre S. Mol Med. 2015; 21(1): 726–734.
Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance. Alzabin S, Kong P, Medghalchi M, Palfreeman A, Williams R, Sacre S. Arthritis Res Ther. 2012;14(3):R142.
Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors. Sacre S, Medghalchi M, Gregory B, Brennan F, Williams R. Arthritis & Rheumatism. 2010;62(3):683-693.
Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease. Midwood K, Sacre S, Piccinini A, Inglis J, Trebaul A, Chan E et al. Nature Medicine. 2009;15(7):774-780.
Inhibitors of toll-like receptor 8 reduce TNF production from human rheumatoid synovial membrane cultures. Sandra M. Sacre, Alexandra Lo, Bernard Gregory, Rachel Simmonds, Lynn Williams, Marc Feldmann, Fionula Brennan, and Brian M. Foxwell. J. Immunol. 2008, 181:8002-9
The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis. Sandra M. Sacre, Evangelos Andreakos, Serafim Kiriakidis, Parisa Amjadi, Anna Lundberg, Grey Giddins, Marc Feldmann, Fionula Brennan, and Brian M. Foxwell. American J. Pathol. 2007, 170 (2), 518-25.
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