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Professor Somnath Mukhopadhyay

Somnath Mukhopadhay 2016

Professor Somnath Mukhopadhyay (MD, PhD, FRCPCH)

Chair in Paediatrics
E: S.Mukhopadhyay@bsms.ac.uk
T: +44 (0)1273 696955 (x62397)
Location: Academic Department of Paediatrics, Royal Alexandra Children's Hospital, Level 6, Room 601, Eastern Road, Brighton, BN2 5BE

DA: Judy Keogh/Katie Isaac

+44 (0)1273 696955 x62409
E: DA.Paediatrics@bsms.ac.uk

Area of expertise: Paediatrics 

Research areas: Asthma, allergy, genomics, personalised treatment strategies

BACKGROUND IMAGE FOR PANEL

Biography

Professor Mukhopadhyay qualified at the University of Calcutta in India. From 1989 to 1992, he was Cystic Fibrosis Clinical Research Fellow (honorary registrar) at the Royal Hospital for Sick Children, University of Bristol. He then became a clinical lecturer (honorary senior registrar) at the Department of Child Health, University of Dundee. Between 1994 and 1997, he was Welcome Trust Advanced Research Training Fellow (honorary senior registrar), also at the University of Dundee. 

BACKGROUND IMAGE FOR PANEL

Research

The aim of Prof Mukhopadhyay's research is to translate the findings of the human genome project to clinical benefit for children with asthma and allergy, through the development of personalised treatment strategies.

In a series of more than 25 key papers over 2007-2017, mostly published in high impact factor journals, he has described the genetic basis for the variation in severity of asthma, eczema and allergy in children in the UK. A proof-of-concept randomised controlled trial has shown that some of these findings can be used to determine more effective choice of asthma medication, thus paving the way for the testing of genotype-based ‘personalised therapy’ in asthma in the clinical arena. Prof Mukhopadhyay was clinical lead for the paper that initially described the role of filaggrin in eczema (Nature Genetics 2006). Prof Mukhopadhyay and colleagues have subsequently described many aspects of the role of filaggrin in atopic disease and they continue to contribute to this important area of research.

Selected publications

Ahmadizar F, Vijverberg SJH, Arets HGM, de Boer A, Turner S, Devereux G, Arabkhazaeli A, Soares P, Mukhopadhyay S, Garssen J, Palmer CNA, de Jongste JC, Jaddoe VW, Duijts L, van Meel ER, Kraneveld AD, Maitland-van der Zee AH. Early life antibiotic use and the risk of asthma and asthma exacerbations in children. Pediatr Allergy Immunol. 2017 Apr 19. doi: 10.1111/pai.12725. [Epub ahead of print]

Mukhopadhyay S, Seddon P, Earl G, Wileman E, Symes L, Olden C, Alberti C, Bremner S, Lansley A, Palmer CN, Beydon N.How can we optimise inhaled beta2 agonist dose as 'reliever' medicine for wheezy pre-school children? Study protocol for a randomised controlled trial.Trials. 2016 Nov 11;17(1):541.

Ahmadizar F, Vijverberg SJ, Arets HG, de Boer A, Lang JE, Kattan M, Palmer CN, Mukhopadhyay S, Turner S, Maitland-van der Zee AH. Childhood obesity in relation to poor asthma control and exacerbation: a meta-analysis. Eur Respir J. 2016 Oct;48(4):1063-1073. doi: 10.1183/13993003.00766-2016. Epub 2016 Sep 1.

Pragmatic randomized controlled trial of an allergy intervention for children aged 6-16 with asthma and rhinitis in general practice. Smith H, Horney D, Jones C, Goubet S, Mukhopadhyay S, Frew A. Clin Exp Allergy. 2016 Sep;46(9):1227-35. doi: 10.1111/cea.12781.

Childhood asthma exacerbations and the Arg16 β2-receptor polymorphism: A meta-analysis stratified by treatment.Turner S, Francis B, Vijverberg S, Pino-Yanes M, Maitland-van der Zee AH, Basu K, Bignell L, Mukhopadhyay S, Tavendale R, Palmer C, Hawcutt D, Pirmohamed M, Burchard EG, Lipworth B; Pharmacogenomics in Childhood Asthma Consortium.J Allergy Clin Immunol. 2016 Jul;138(1):107-113.e5. doi: 10.1016/j.jaci.2015.10.045. Epub 2016 Jan 7.

Lipworth BJ, Basu K, Donald HP, Tavendale R, Macgregor DF, Ogston SA, Palmer CN, Mukhopadhyay S. Tailored second-line therapy in asthmatic children with the Arg(16) genotype. Clinical Science 2013 Apr;124(8):521-528.

Cunningham J, Basu K, Tavendale R, Palmer CN, Smith H, Mukhopadhyay S.The CHI3L1 rs4950928 polymorphism is associated with asthma-related hospital admissions in children and young adults. Ann Allergy Asthma Immunol. 2011 May;106(5):381-6. 

Koster ES, Maitland-van der Zee AH, Tavendale R, Mukhopadhyay S, Vijverberg SJ, Raaijmakers JA, Palmer CN. FCER2 T2206C variant associated with chronic symptoms and exacerbations in steroid-treated asthmatic children. Allergy. 2011 Dec;66(12):1546-52. doi: 10.1111/j.1398-9995.2011.02701.x. Epub 2011 Sep 29.

Huang JT, Chaudhuri R, Albarbarawi O, Barton A, Grierson C, Rauchhaus P, Weir CJ, Messow M, Stevens N, McSharry C, Feuerstein G, Mukhopadhyay S, Brady J, Palmer CN, Miller D, Thomson NC. Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease. Thorax. 2012 Jun;67(6):502-8. Epub 2012 Jan 16.

Turner SW, Ayres JG, Macfarlane TV, Mehta A, Mehta G, Palmer CN, Cunningham S, Adams T, Aniruddhan K, Bell C, Corrigan D, Cunningham J, Duncan A, Hunt G, Leece R, MacFadyen U, McCormick J, McLeish S, Mitra A, Miller D, Waxman E, Webb A, Wojcik S, Mukhopadhyay S, Macgregor D.  A methodology to establish a database to study gene environment interactions for childhood asthma. BMC Med Res Methodol. 2010 Dec 6; 10:107