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Brighton & Sussex Medical School

Current studies

Current studies

The Brighton and Sussex Clinical Trials Unit is currently supporting the following studies:

A Randomised Controlled Trial of an Online Intervention to Prevent Anxiety in the Children of Anxious Parents

Acronym: PWA

Trial status: Recruiting

Disease area: Anxiety

Funder: The Kavli Foundation

More about our PWA study >

BACKGROUND IMAGE FOR PANEL

Palliative Long-term Abdominal Drains Versus Repeated Drainage in Untreatable Ascites Due to Advanced Cirrhosis: A Randomised Controlled Trial (REDUCe 2 Study)

Acronym: REDUCe2

Trial status: In set up

Disease area: Hepatology

Funder: National Institute for Health Research (NIHR), Health Technology Assessment (HTA) Programme 

More about our REDUCe2 study >

BACKGROUND IMAGE FOR PANEL

Increasing access to CBT for psychosis patients: a randomized controlled trial evaluating brief, targeted CBT for distressing voices delivered by Assistant Psychologists

Acronym: GiVE3

Trial status: In set up

Disease area: Mental Health

Funder: National Institute for Health Research (NIHR), Research for Patient Benefit (RfPB)

More about our GIVE3 study >

Evaluating the Home-based Intervention Strategy (HIS-UK) to reduce new chlamydia infection among young men aged 16-25 years by promoting correct and consistent condom use: What is the cost effectiveness of two different delivery models (face-to-face and digital delivery)? 

Acronym: HIS UK 

Trial status: In set up

Disease area: Sexual health/ infection

Funder: National Institute for Health Research (NIHR), Public Health Research (PHR) Programme 

more about our HIS UK Study >

BACKGROUND IMAGE FOR PANEL

A Phase IV Randomised, Open-Label Pilot Study to Evaluate Switching from Protease-Inhibitor based regimen to Bictegravir/Emtricitabine/Tenofovir Alafenamide Single Tablet Regimen in Integrase Inhibitor-naïve, virologically suppressed HIV-1 infected adults harbouring drug resistance mutations 

Acronym: PIBIK STUDY 

Trial status: Recruiting

Disease area: Virologically suppressed HIV-1 infected adults harbouring drug resistance mutations

Funder: Gilead Sciences, Inc 

more about our PIBIK Study >

BACKGROUND IMAGE FOR PANEL

High Flow humidified oxygen as an early intervention in children with Acute Severe Asthma: a feasibility study 

Acronym: HiFlo ASA

Trial status: In set up

Disease area: Paediatric asthma

Funder: NIHR 

more about our HiFlo ASA Study >

A phase IV, open-label, pilot study investigating non-invasive markers of hepatic fibrosis in people living with HIV-1 and non-alcoholic fatty liver disease randomised to receiving optimised background therapy (OBT) plus maraviroc or OBT

Acronym: HEPMARC  

Trial status: Closed

Disease area: Liver disease

MORE about our HEPMARC Study >

BACKGROUND IMAGE FOR PANEL

The Early Youth Engagement in first episode psychosis (EYE-2) study: pragmatic cluster randomised controlled trial of implementation, effectiveness & cost effectiveness of a team-based motivational engagement intervention to improve engagement

Acronym: EYE-2 

Trial status: Closed

more about our EYE-2 Study >

BACKGROUND IMAGE FOR PANEL

Completed studies

LIGHTMind 2

Low-Intensity Guided Help Through Mindfulness: A randomised controlled trial comparing supported mindfulness-based cognitive therapy self-help to supported cognitive behaviour therapy self-help for adults experiencing depression.

CHILLY-AF

A randomised comparison of cardioversion and catheter cryoablation in patients with persistent atrial fibrillation.

HYVET-2 

A Phase IV, Multi-Centred, Open Label, Randomised Study Assessing the Cardiovascular Outcomes Following Treatment of White Coat Hypertension with Established Anti-Hypertensive Drugs versus Standard of Care in the Very Elderly – Feasibility Study.

EndoPredict 

The Use of a prognostic tool (EndoPredict®) to inform adjuvant chemotherapy decisions in low to medium risk Oestrogen Receptor Positive, Her-2 Negative Early Breast cancer: Feasibility, Acceptability and Economic impact in Multicentre UK NHS Practice.

EVIDEnT

Laboratory observational Ex-Vivo study to investigate the sensitivity and specificity of a smart dressing to detect clinically relevant wound infection.

OpSal

How can we optimise inhaled beta2 agonist dose as 'reliever' medicine for wheezy pre-school children? 

Pooled Swab

A study to estimate the site-specific prevalence of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) at pharyngeal, urethral and rectal sites in men who have sex with men (MSM) and to evaluate the performance of pooling self-collected samples for the detection of these infections in one sample using the BD ProbeTec™ GC/CT Qx Amplified DNA Assay.

REDUCe

Palliative long-term abdominal drains versus repeated drainage in individuals with untreatable ascites due to advanced cirrhosis: a feasibility randomised controlled trial. 

RIIiO

Pilot study for a randomised trial comparing the influence of forced air versus resistive fabric warming technologies on post-operative infection rates following orthopaedic implant surgery in adults.