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Brighton & Sussex Medical School

Current studies

Current studies

The Brighton and Sussex Clinical Trials Unit is currently supporting the following studies:

Evaluating the Home-based Intervention Strategy (HIS-UK) to reduce new chlamydia infection among young men aged 16-25 years by promoting correct and consistent condom use: What is the cost effectiveness of two different delivery models (face-to-face and digital delivery)? 

Acronym: HIS UK 

Trial status: In set up

Disease area: Sexual health/ infection

Funder: National Institute for Health Research (NIHR), Public Health Research (PHR) Programme 

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BACKGROUND IMAGE FOR PANEL

A Phase IV Randomised, Open-Label Pilot Study to Evaluate Switching from Protease-Inhibitor based regimen to Bictegravir/Emtricitabine/Tenofovir Alafenamide Single Tablet Regimen in Integrase Inhibitor-naïve, virologically suppressed HIV-1 infected adults harbouring drug resistance mutations 

Acronym: PIBIK STUDY 

Trial status: In set up

Disease area: Virologically suppressed HIV-1 infected adults harbouring drug resistance mutations

Funder: Gilead Sciences, Inc 

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BACKGROUND IMAGE FOR PANEL

High Flow humidified oxygen as an early intervention in children with Acute Severe Asthma: a feasibility study 

Acronym: HiFlo ASA

Trial status: Recruiting

Disease area: Paediatric asthma

Funder: NIHR 

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BACKGROUND IMAGE FOR PANEL

A Phase IV, Multi-Centred, Open Label, Randomised Study Assessing the Cardiovascular Outcomes Following Treatment of White Coat Hypertension with Established Anti-Hypertensive Drugs versus Standard of Care in the Very Elderly – Feasibility Study

Acronym: HYVET-2 

Trial status: Recruiting

Disease area: Hypertension

Funder: Dunhill Medical Trust

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A phase IV, open-label, pilot study investigating non-invasive markers of hepatic fibrosis in people living with HIV-1 and non-alcoholic fatty liver disease randomised to receiving optimised background therapy (OBT) plus maraviroc or OBT

Acronym: HEPMARC  

Trial status: Recruiting

Disease area: Liver disease

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BACKGROUND IMAGE FOR PANEL

The Early Youth Engagement in first episode psychosis (EYE-2) study: pragmatic cluster randomised controlled trial of implementation, effectiveness & cost effectiveness of a team-based motivational engagement intervention to improve engagement

Acronym: EYE-2 

Trial status: In preparation

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BACKGROUND IMAGE FOR PANEL

A randomised comparison of cardioversion and catheter cryoablation in patients with persistent atrial fibrillation

Acronym: CHILLY-AF

Trial status: Recruiting

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Low-Intensity Guided Help Through Mindfulness: A randomised controlled trial comparing supported mindfulness-based cognitive therapy self-help to supported cognitive behaviour therapy self-help for adults experiencing depression 

Acronym: LIGHTMind 2

Trial status: Recruiting

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BACKGROUND IMAGE FOR PANEL

Completed studies

EndoPredict 

The Use of a prognostic tool (EndoPredict®) to inform adjuvant chemotherapy decisions in low to medium risk Oestrogen Receptor Positive, Her-2 Negative Early Breast cancer: Feasibility, Acceptability and Economic impact in Multicentre UK NHS Practice.

EVIDEnT

Laboratory observational Ex-Vivo study to investigate the sensitivity and specificity of a smart dressing to detect clinically relevant wound infection.

OpSal

How can we optimise inhaled beta2 agonist dose as 'reliever' medicine for wheezy pre-school children? 

Pooled Swab

A study to estimate the site-specific prevalence of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) at pharyngeal, urethral and rectal sites in men who have sex with men (MSM) and to evaluate the performance of pooling self-collected samples for the detection of these infections in one sample using the BD ProbeTec™ GC/CT Qx Amplified DNA Assay.

REDUCe

Palliative long-term abdominal drains versus repeated drainage in individuals with untreatable ascites due to advanced cirrhosis: a feasibility randomised controlled trial. 

RIIiO

Pilot study for a randomised trial comparing the influence of forced air versus resistive fabric warming technologies on post-operative infection rates following orthopaedic implant surgery in adults.