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Brighton & Sussex Medical School

Current studies

Current studies

The Brighton and Sussex Clinical Trials Unit is currently supporting the following studies:

BACKGROUND IMAGE FOR PANEL

HeartRater: Clinical. Optimizing ADIE therapy for the treatment of anxiety in underserved populations 

Acronym: HeartRater

Trial status: Recruiting

Disease area: Mental health

Funder: Medical Research Council

Find out more about Heartrater >

Outdoor swimming as a nature-based intervention, offered in addition to usual care, compared to a group receiving usual care alone, in people with depression: a full-scale Randomised Controlled Trial

Acronym: Outside 2

Trial status: Recruiting

Disease area: Mental health

Funder: National Institute for Health and Care Research (NIHR)

FIND OUt MORE ABOUT Outside 2 >

BACKGROUND IMAGE FOR PANEL

Impact of duration of antibiotic therapy on effectiveness, safety and selection of antibiotic resistance in adult women with urinary tract infections (UTI): a randomised controlled trial

Acronym: DURATION-UTI

Trial status: Recruiting

Disease area: Infection

Funder: National Institute for Health and Care Research (NIHR)

More about DURATION-UTI study >

BACKGROUND IMAGE FOR PANEL

Palliative Long-term Abdominal Drains Versus Repeated Drainage in Untreatable Ascites Due to Advanced Cirrhosis: A Randomised Controlled Trial (REDUCe 2 Study)

Acronym: REDUCe2

Trial status: Recruiting

Disease area: Hepatology

Funder: National Institute for Health and Care Research (NIHR), Health Technology Assessment (HTA) Programme 

more about the REDUCe2 study >

High Flow humidified Oxygen in Paediatric Severe Asthma

Acronym: HOPSA

Trial status: In set up

Disease area: Paediatrics

Funder: NIHR RfPB

More about the HOPSA study >

BACKGROUND IMAGE FOR PANEL

A feasibility randomised controlled trial of a novel postural management night-time intervention (Breathe-Easy) to improve respiratory health of children with complex neurodisability

Acronym: ADAPT

Trial status: Recruiting

Disease area: Paediatrics

Funder: NIHR RfPB

More about the ADAPT study >

BACKGROUND IMAGE FOR PANEL

Completed studies

CHILLY-AF
A randomised comparison of cardioversion and catheter cryoablation in patients with persistent atrial fibrillation.

EndoPredict 

The Use of a prognostic tool (EndoPredict®) to inform adjuvant chemotherapy decisions in low to medium risk Oestrogen Receptor Positive, Her-2 Negative Early Breast cancer: Feasibility, Acceptability and Economic impact in Multicentre UK NHS Practice.

EVIDEnT

Laboratory observational Ex-Vivo study to investigate the sensitivity and specificity of a smart dressing to detect clinically relevant wound infection.

EYE-2

The Early Youth Engagement in first episode psychosis (EYE-2) study: pragmatic cluster randomised controlled trial of implementation, effectiveness & cost effectiveness of a team-based motivational engagement intervention to improve engagement. 

HEPMARC 

A phase IV, open-label, pilot study investigating non-invasive markers of hepatic fibrosis in people living with HIV-1 and non-alcoholic fatty liver disease randomised to receiving optimised background therapy (OBT) plus maraviroc or OBT.

HiFlo ASA

High Flow humidified oxygen as an early intervention in children with Acute Severe Asthma: a feasibility study.

HYVET-2 

A Phase IV, Multi-Centred, Open Label, Randomised Study Assessing the Cardiovascular Outcomes Following Treatment of White Coat Hypertension with Established Anti-Hypertensive Drugs versus Standard of Care in the Very Elderly – Feasibility Study.

LIGHTMind 2

Low-Intensity Guided Help Through Mindfulness: A randomised controlled trial comparing supported mindfulness-based cognitive therapy self-help to supported cognitive behaviour therapy self-help for adults experiencing depression.

OpSal

How can we optimise inhaled beta2 agonist dose as 'reliever' medicine for wheezy pre-school children? 

REDUCe

Palliative long-term abdominal drains versus repeated drainage in individuals with untreatable ascites due to advanced cirrhosis: a feasibility randomised controlled trial. 

RIIiO

Pilot study for a randomised trial comparing the influence of forced air versus resistive fabric warming technologies on post-operative infection rates following orthopaedic implant surgery in adults. 

PWA

A Randomised Controlled Trial of an Online Intervention to Prevent Anxiety in the Children of Anxious Parents.

GIVE3

Increasing access to CBT for psychosis patients: a randomized controlled trial evaluating brief, targeted CBT for distressing voices delivered by Assistant Psychologists.

HIS-UK

Evaluating the Home-based Intervention Strategy (HIS-UK) to reduce new chlamydia infection among young men aged 16-25 years by promoting correct and consistent condom use: What is the cost effectiveness of two different delivery models (face-to-face and digital delivery)? 

PIBIK

A Phase IV Randomised, Open-Label Pilot Study to Evaluate Switching from Protease-Inhibitor based regimen to Bictegravir/Emtricitabine/Tenofovir Alafenamide Single Tablet Regimen in Integrase Inhibitor-naïve, virologically suppressed HIV-1 infected adults harbouring drug resistance mutations.