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Brighton & Sussex Medical School

Predicting CRF in Women

BSMS > Research > Clinical and experimental medicine > Cancer > Predicting CRF in Women

Predicting CRF in Women

This PhD project explores cancer-related fatigue (CRF) in people living with and beyond cancer, with a particular interest in how biological, psychological, and lifestyle factors shape the experience of fatigue over time.

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About the project

This PhD project explores cancer-related fatigue (CRF) in people living with and beyond cancer, with a particular interest in how biological, psychological, and lifestyle factors shape the experience of fatigue over time. Rather than looking at CRF from a single angle, this work focuses on how these different influences interact and contribute to why some people develop persistent or severe fatigue while others do not.  

The project aims to build a clearer understanding of CRF that can support earlier identification of those at risk and help guide more personalised and effective approaches to managing fatigue throughout and after cancer treatment.  

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Research aims

Primary

  1. To integrate proteomic, psychosocial, clinical and behavioural data to create predictive models capable of predicting cancer-related fatigue in women with breast and ovarian cancer.  

Secondary

  1. Characterise the development of CRF over the course of treatment and recovery, identifying subgroups with distinct fatigue trajectories and the factors that distinguish them.  
  2. Examine how CRF relates to health-related quality of life, stress, anxiety, depression, self-efficacy, social support, physical activity and clinical characteristics.  
  3. Determine whether specific proteins or proteomic pathways are associated with psychosocial or clinical measures and explore shared biological mechanisms underlying CRF and its comorbid symptoms.  
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