Tackling Antimicrobial Resistance (AMR)
The rise in the rates of bacterial resistance to antimicrobials is alarming as increasing number of countries report resistance to all of the commonly used antimicrobials. AMR impedes effective treatment and prevention of infection which, compromises patient outcomes and can lead to untreatable fatal infections and global spread of resistant organisms. The WHO fear that without intervention more people will die of AMR-related infections than from cancer by 2050. Misuse of antimicrobial agents in people and animals is a dominant driving force.
Our group represent a network of cross-disciplinary researchers who are passionate about tackling AMR by understanding factors contributing towards its development and implementing strategies to optimise antimicrobial use particularly in low- and middle-income countries where significant data gaps exist.
AMR areas of research at BSMS
Epidemiology of Gram-negative and Gram-positive infections
An interdisciplinary project, run by Dr Leena Al-Hassan, aims to investigate the epidemiology of Gram-negative infections and characterise the main mechanisms of antibiotic resistance in different African countries, as well as looking at the role of mobile genetic elements in the transmission of resistance globally.
Research includes the epidemiology of both Gram-negative and Gram-positive infections, genetic mechanisms of resistance, evolution and transmission in the hospital setting, as well as the community, and antimicrobial stewardship.
Application of microbial genome sequencing
A team working with Prof Martin Llewelyn is currently looking at application of microbial genome sequencing to the study of transmission and pathogenesis of S. aureus infection and reducing antibiotic usage in hospitals through optimising treatment strategies. This is in collaboration with groups such as Modernising Medical Microbiology, the International Staphylococcus Aureus Collaboration and the NIHR-funded Antibiotic Reduction and Conservation in Hospitals (ARK-Hospital) programme.
Antibiotic Review Kit (ARK) Hospital
ARK-Hospital is an NIHR Programme Grants for Applied Research funded project developing a complex behaviour-change intervention to substantially and safely reduce antibiotic overuse in hospitals. Further information can be found on the project website www.arkstudy.ox.ac.uk. Prof Llewelyn is leading the clinical trial and the faecal ‘resistome’ sub-study.
FORESIGHT is a European Stakeholder Appraisal of Diagnostics to Manage Antimicrobial Resistance This is a collaboration between the University of Sussex Science Policy Research Unit (SPRU) and the Office for Health Economics. It is funded by the MRC.
The Consensus on Antimicrobial Stewardship Evaluations (CASE) Working Group led by Prof Llewelyn is an international initiative funded by the Joint Programme Initiative on AMR (JPIAMR) through the MRC. It is developing guidance for funders and researches on how antimicrobial stewardship interventions should be evaluated.
Prioritising Antimicrobial Resistance: Establishing an Interdisciplinary International Research Network (IRPN) to Tackle an Evolving Global Health Threat
A research partnership between the Wellcome Trust Brighton and Sussex Centre for Global Health Research (WTBSCGHR), The Centre for Global Health Policy (CGHP) at the University of Sussex, The Institute of Global Health (ISGlobal) at the University of Barcelona, and the Institute of Medical Microbiology, Immunology and Hygiene (IMMIH) at the University of Cologne.
These institutes have different, but overlapping, research experience and the IRPN partners form a global, collaborative, research network, including Egypt, Sudan, Ethiopia, Morocco, Mozambique, Cameroon, Bolivia and Peru. The partnership aims to obtain insight into the epidemiology of resistance at a global level, expand research and learning in novel technologies in whole-genome sequencing (WGS) to better understand the genetics of pathogens, and to gather data on the social and policy drivers that shape the evolution of resistance.
Building global surveillance data: towards a sustainable global response to AMR
In collaboration with the School of Global Studies and the Institute of Development Studies (IDS), a Sussex Sustainability and Research Programme (SSRP) fund was awarded to this project which aims to improve the knowledge base of the global AMR response by investigating how global surveillance systems can be linked better into local health system in LMICs.
The project will track the life-cycle of data that is produced in routine clinical practice and follow its trajectory in local healthcare facilities, the health system and the policy level as well as using molecular diagnostics (including whole-genome sequencing) on bacterial samples from hospitalised patients.
The Sussex Antimicrobial Resistance Study Group
The AMR study group serves as a platform to generate transformative knowledge through interdisciplinary collaborations. We hold regular meetings to share research expertise, engage in new ways of thinking about critical issues, and to develop partnerships, projects, and publications aimed a range of audiences, in order to contribute to addressing the challenge of AMR.
MORE about Sussex AMR Study Group >
Researchers working on AMR projects
Please click on each name to read more about their specific projects.
Prof Martin Llewelyn >
Dr Leena Al-Hassan >
Dr Jas Islam >
PhD and Postdoc students working on AMR
Academic Clinical Fellows
Maho Yokoyama >